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In ME/CFS and Long COVID, a phenomenon often referred to as the "mitochondrial doom loop" occurs
DOI: 10.1097/MED.0000000000000576
J Neurosci 19(18):79837990 Chen ZY, Patel PD, Sant G, Meng CX, Teng KK, Hempstead BL, Lee FS (2004) Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wildtype BDNF in neurosecretory cells and cortical neurons
Stubborn visceral abdominal fat, difficulty gaining lean muscle, poor body composition despite consistent training and nutrition, slow recovery, disrupted sleep, and age-related growth hormone decline
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