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10.1016/j.toxlet.2016.06.008 Toxicol
Best for users willing to commit to daily or every-other-day dosing and blood work monitoring
Furthermore, after losing membrane potentials, defective mitochondria would be degraded by mitophagy (Jin et al., 2021)
The third level is causal proof, such as loss of effect after pathway inhibition or restoration of effect after pathway rescue
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