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For selected patients, obesity treatment may involve more than one tool rather than a choice of medication or procedure alone

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This mechanism: Increases urinary glucose excretion , effectively removing excess glucose from the body Produces a modest reduction in blood pressure through mild diuretic effects Offers cardiovascular and renal benefits in specific patient populations, as demonstrated in clinical trials and reflected in its licensed indications Results in modest weight loss (typically 2-3 kg) due to calorie loss through glucose excretion Because these medications work through completely different pathwaysone affecting gut hormones and appetite regulation, the other affecting kidney glucose handlingthey can complement each other when managing complex metabolic conditions

Surprisingly, these phenotypic consequences of CBP/p300 inhibition did not result in viability defects in NRF2-dependent cell lines