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The study excluded those without T2D or obesity at baseline
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Gut leakiness can be treated in these conditions using medications to control the underlying inflammation or infection (or a strict gluten free diet in the case of coeliac disease).(3, 4) Alcohol and certain medications (especially non-steroidal anti-inflammatory drugs (NSAIDs) like aspirin and ibuprofen) are also gut irritants that can affect the tight junctions between cells in the gut barrier, making them more leaky.(5) This usually causes little harm or symptoms if use is short term or infrequent, however prolonged exposure can lead to inflammation of the bowel and development of ulcers.(5) Whether or not changes in gut barrier function are part of the cause of IBS continues to be debated.(1, 2) Of the small number of studies looking at intestinal barrier dysfunction in IBS patients, most have focused on those with diarrhoea predominant symptoms
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Within experimental models, researchers frequently investigate Melanotan II in relation to receptor activation pathways, intracellular signalling mechanisms and peptide-mediated regulatory networks
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