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The results were confirmed for the non-related enzyme PfGrx with its homologous residues Lys26 and Asp90
That structural feature is significant: proline residues resist proteolytic cleavage, making the peptide unusually stable in gastric conditions relative to most short peptides [1]
Potential BPC 157 benefits include: Tendon and ligament repair support Joint and soft-tissue recovery Reduced inflammatory signaling Gastrointestinal mucosal support Wound-healing support Recovery from training-related irritation or overuse These effects distinguish BPC 157 from peptides primarily used for hormone modulation
The dosing regimen varies depending on whether neurological symptoms are present: With neurological involvement: 1 mg intramuscularly on alternate days until no further improvement, then 1 mg every 2 months [3] [4] Without neurological involvement: 1 mg intramuscularly three times a week for 2 weeks, then 1 mg every 2-3 months for maintenance [3] [4] There is some evidence that high-dose oral B12 (1000-2000 micrograms daily) may be effective even in some malabsorption conditions, though UK practice still generally favours intramuscular treatment in these cases
78 NicolaeA.MitreaN.DrgoiM.ConstantinescuZ.CiofrangeanuC.BarboiG.et al (2013)
