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A geometrical constraint (along dihedral angles and ) was applied to facilitate the conformational change along a pre-defined pathway from the starting conformer (T or R) to the known target conformer (R or T)
Notably, patients carrying the apolipoprotein E epsilon-4 allele, the strongest genetic risk factor for Alzheimer disease, showed the highest BDNF responses to cerebrolysin treatment
For drug testing purposes, standard employment drug panels do not test for peptides
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