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Wang M, Hu Y, Xu Y, Hu W, Zheng H, Zhang M, et al
Among the salient indications, inhaled NO is used for acute pulmonary vasoreactivity testing and severe hypoxia in pulmonary arterial hypertension (PAH), nitrates are used extensively in ischemic heart disease and heart failure, sGC stimulators and activators are used for PAH, and PDE5 inhibitors are used for erectile dysfunction, PAH and benign prostatic hyperplasia
Singh AV, Bhardwaj P, Laux P, Pradeep P, Busse M, Luch A, Hirose A, Osgood CJ, Stacey MW
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Evidence summarized by Peptide Sciences notes that copper(II) ions can inhibit type 1 5--reductase activity by up to ~90% in vitro (half-maximal inhibition at ~0.12 g/mL Cu), with substantially less effect on type 2 suggesting follicle-localized DHT suppression without system-wide androgen blockade
