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A clinical trial comparing GHK-Cu to Matrixyl 3000 (one of the most popular anti-aging peptide ingredients in skincare) showed GHK-Cu produced a 55.8% reduction in wrinkle volume compared to control and a 31.6% reduction compared to Matrixyl 3000 itself

Int J Mol Med 13:537543 Seidel E, Ragan V (1997) Inhibition by rapamycin of ornithine decarboxylase and epithelial cell proliferation in intestinal IEC-6 cells in culture

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Activating GLP-1, GIP, and glucagon receptors simultaneously puts more stress on the gastrointestinal system during the adaptation period