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Indeed, lymphocyte proliferation was enhanced up to 60% within one week and Natural Killer cell cytotoxicity was increased up to 400% as early as week 2

However, our included studies intervening with a dosage higher than 2000mg/d seemed to show more benefit to patients [9,10], while one subgroup [9] with 1500mg/d showed less reduction in VAS (p value not provided)

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Jiao W, Lin J, Deng Y, et al