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This might be a potential connection to GM and thyroid regulation suggested initially by the Harries (1923) more than hundred years back (Harries 1923)

December 8, 1923

Understand the difference between insoluble versus soluble fiber and more in this article from GobyMeds

When energy intake drops sharply and fat stores deplete rapidly, the hypothalamic-pituitary axis responds by downregulating processes deemed non-essential for survival

Motif analysis of downregulated genes in both Ndufs2 and Bmal1 KO adipocytes revealed shared enrichment for C/EBP and SP family transcription factor motifs (Fig