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Other recognised adverse effects of Wegovy include: Fatigue and dizziness (which might be confused with seizure-related symptoms) Increased heart rate (typically modest, around 14 beats per minute) Gallbladder problems (cholelithiasis) Pancreatitis (rare but serious) Important additional safety considerations include: Pregnancy and breastfeeding : Wegovy is contraindicated during pregnancy and breastfeeding
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The FDA approved once-daily oral semaglutide (Wegovy) at 25 mg on 22 December 2025, making it the first oral GLP-1 approved specifically for chronic weight management in the US
The research on this is pretty new, but it will be interesting to see whether part of the reason MAO inhibitors work for depression is due, at least in part, to decreasing neuroinflammation, which is a root cause of depression for some people.[ref] Related article : Inflammation as a cause of depression MAOA: Heart valves and varicose vein connections I mentioned above that MAO-A is found abundantly in the heart