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Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of medications primarily used to manage type 2 diabetes mellitus and, more recently, for weight management in adults with obesity or overweight with comorbidities

Excess is safely excreted

This should be monitored, particularly in patients with pre-existing cardiovascular conditions

Increased protein intake alone is unlikely to preserve muscle mass in the absence of resistance training

It enhances both synthesis and breakdown of extracellular matrix components, such as collagen, glycosaminoglycans (including dermatan and chondroitin sulfate), and decorin, and regulates metalloproteinases and their inhibitors (Pickart, Vasquez-Soltero, and Margolina 2015)