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Modern clinical research has shown that saffron supplementation (typically 2050mg per day) can improve visual acuity, retinal function, and contrast sensitivity in adults with AMD.58 These effects are attributed to compounds called crocin and crocetin, which may enhance retinal blood flow and protect photoreceptor cells from oxidative stress
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doi: 10.1111/jcmm.14591 259 YueTFanXZhangZLiuZGuoMBaiFet al
Glutathione S-transferases and prevention of cellular free radical damage [PMID: 9736316] Laboratory literature summary: Glutathione S-transferases and prevention of cellular free radical damage
Until safety data exists, avoiding use during these periods is the only prudent approach
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