does glp 1 wear off Can You Take a GLP-1 Drug Less Often if You're at Your Goal Weight? When you’ve been on a

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Effect of IGF-1 on protein metabolism in burned rats [PMID: 10483905] Laboratory literature summary: Effect of IGF-1 on protein metabolism in burned rats

Studies indicate that any reduction in metabolic rate during GLP-1 treatment is primarily attributable to: Decreased body mass : A smaller body naturally requires less energy for basic physiological functions Loss of metabolically active tissue : Both fat and lean tissue contribute to resting energy expenditure Normal adaptive thermogenesis : The body's natural response to caloric restriction and weight loss Comparative studies examining GLP-1-induced weight loss versus equivalent weight loss through diet and exercise show similar metabolic adaptations, suggesting the medications do not cause additional metabolic suppression beyond what would be expected with weight loss by any means

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