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Baliga MS, Wang H, Zhuo P, Schwartz JL, Diamond AM

Current clinical and experimental evidence indicates that pathogens primarily enter the thoracic duct via the mesenteric lymph nodes and subsequently settle in various organs, including the left subclavian vein (Wang et al., 2019)

Considering the latter possibility, treatments that were considered failures in previous clinical trials could be reanalyzed for potential efficacy in ALS, taking into account the duration of the disease at the start of therapy. Therefore, using diagnostic criteria that enables earlier identification of the disease and a change in the physicians attitude towards offering an early diagnosis and treatment could result in better ALS patient outcomes.

BPC-157s apparent promotion of cell motility and survival might translate into more robust collagen deposition and alignment, as it potentially helps the fibroblasts migrate into the injury site and lay down extracellular matrices rich in type I and III collagen

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