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Through correlation analysis and transcription factor enrichment screening, HNF4 emerged as a candidate upstream regulator [43]

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Studies document IGF-1 LR3 effects on: Adipose tissue insulin sensitivity Triglyceride hydrolysis rates Free fatty acid mobilisation Mitochondrial oxidative capacity in adipocytes These effects may contribute to the metabolic recomposition observed in some research models, though the balance between anabolic and catabolic effects remains dependent on nutritional state and exercise status