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Glutathione, the principal antioxidant and detoxifying agent produced by the liver, helps neutralise toxins, pollutants, and metabolic wastes, allowing them to be eliminated from the body more easily

The full article is full of references and clinical trial data on nattokinase

However, due to receptor-level adaptations and downstream neuroplastic changes, clinical efficacy typically requires 46 weeks of continuous administration

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Similarly, the STEP 4 trial found that patients who discontinued semaglutide and switched to a placebo for 48 weeks regained 6.9% of their body weight