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Mechanistic validation further confirmed downregulated expression of Nrf2, HO-1, and GPX4 in CLP mice, establishing a direct link between glutathione dysregulation and neuronal apoptosis

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Related expressional change of HIF-1 to the neuroprotective activity of exendin-4 in transient global ischemia

1997 Sexual Function Arousal Pathway Models Preclinical research using MTII as a non-selective MC agonist probe contributed to the discovery of melanocortin-mediated arousal pathways, eventually leading to the development of PT-141 (bremelanotide) as a more selective MC4R-focused compound