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Studies suggest 25-40% of weight lost may come from muscle rather than fat
As men age, mitochondrial function tends to decline due to damage accumulated over time and the reduced efficacy of mitochondrial DNA repair mechanisms
3.7 GRADE assessment In the GRADE assessment, the HR effects for nonfatal stroke and UA hospitalization were downgraded to moderate due to imprecision [no statistically significant results and total event counts below the optimal information size (OIS) threshold]
* Based on the efficacy estimand: estimated efficacy in an idealized scenario in which all patients stayed on treatment and took no other weight loss therapies
26 , 267277.e262 (2017)
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