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The biggest concern about these unregulated peptides is the lack of adequate human clinical evidence for the uses they are being marketed for, says Rita Jew, PharmD, president at the Institute for Safe Medication Practices in San Francisco
Acquired resistance often originates from preexisting heterogeneity within the tumor and is further shaped by continuous diversification during therapy, enabling certain subclones to survive therapeutic pressure and eventually emerge as dominate resistant phenotypes
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Referensi: Dermatology Research and Practice
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