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The researchers suspected this was partly rebound weight gain from discontinuing the medication
Key Takeaways Semaglutide and other GLP-1 medications can cause bloating by slowing digestion, allowing food and gas to remain in the stomach longer
This system allowed for the investigation of crosstalk between senescent Leydig cells and spermatogonia
Semaglutide appears to activate AMPK, which aids in restoring metabolic balance (Zhai et al., 2025)
Reducing from 12mg to 9mg might resolve symptoms while maintaining substantial weight loss (25.926.4% at 9mg vs 28.328.7% at 12mg across Phase 3 trials)
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