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Loading Phase (Weeks 1-4): 2 to 2.5 mg twice weekly (Monday/Thursday schedule) Maintenance Phase (Weeks 5+): 2 mg once every 7 to 14 days Administration: Subcutaneous injection, location flexible due to systemic distribution Total Cycle: 8 to 12 weeks with 4 to 8 weeks off between cycles The convenience of twice-weekly dosing during loading and weekly or biweekly dosing during maintenance fits easily into Retatrutide schedules
These are given either in the muscle (intramuscularly) or under the skin (subcutaneously)
The pairing is studied so often precisely because the two compounds operate through distinct, complementary mechanisms rather than overlapping ones meaning a combined protocol covers more of the regenerative pathway landscape than either compound alone
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