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Single doses of 42, 140, 420 and 1260 mg intravenously were well tolerated and showed dose-proportional, linear pharmacokinetics, with the half-life increasing with the dose Ruff et al., 2010
The order and timing of application matter significantly
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Amount of vitamin b12 that reaches blood: Vitamin B12 Injection For Dogs Delivers Larger Amount Of Cobalamin In Blood-Picture Courtesy: MetLife Pet Insurance By giving vitamin b12 orally, you cannot estimate what amount of nutrient that has reached the blood
The right volume depends on your target concentration, your syringe type, and your dosing protocol
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