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further demonstrates that histone lactylation is a novel epigenetic mark that stimulates gene transcriptional activity on chromatin in response to elevated intracellular lactate levels, and is particularly prominent during M1-type macrophage polarization

This is a difficult, often moving-target objective

This may have to do with its interaction with other hormones, such as serotonin (known popularly as the happy hormone), which is a neurotransmitter involved in mood and appetite regulation, and sex hormone-binding globulin (SHBG)

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This study further developed a cell death-related signature (CDS) based on CASP1, CYBB, PLA2G4A, and CTSS, providing an effective diagnostic tool that tightly correlates with progressive renal function decline and local immune microenvironment remodeling (135)