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407 These siRNAs eliminate the DN effect and depend on mutant p53 to induce cell death and inhibit tumor growth in xenografts
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It also inhibits the expression of phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase), key enzymes in gluconeogenesis (Hardie et al
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The drug is a once-daily injection that is particularly useful for controlling after-meal blood glucose levels early trial results suggested it may be even better than Novo Nordisks Victoza specifically for post-meal spikes, but perhaps not in other areas of glucose control
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