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For outcomes with significant findings in some groups, the direction of effects was consistent, although statistical significance was not achieved in all populations

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This work was supported by the Japan Society for the Promotion of Science KAKENHI (21H04811 and 22K19405), AMED (JP23ek0109521), Daiichi Sankyo Foundation of Life Science, The NOVARTIS Foundation (Japan) for the Promotion of Science and G-7 Scholarship Foundation

Adults and children over 16 years of age, one tablet daily on an empty stomach