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In heterodimeric GST complexes such as those formed by the cytosolic mu and alpha classes, however, the cleft between the two subunits is home to an additional high-affinity nonsubstrate xenobiotic binding site, which may account for the enzymes' ability to form heterodimers

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Notably, 1 O exihibits a high degree of chemical reactivity, allowing it to directly target lipids, proteins, and DNA in cell membranes, thereby inducing oxidative damage [88]

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