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Importantly, wild-type BoNT/X protease did not induce notable apoptotic or lytic cell death (Extended Data Fig

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In addition to destroying the cell membrane's fluidity and stability, LOOH may enhance the membrane's permeability, which in turn causes lipid membrane rupture and, eventually, ferroptosis [63,66,67]

By integrating antioxidants, mitophagy regulators, and immunomodulators, future mitochondria-focused strategies hold promise for limiting infection-induced tissue damage, enhancing antiparasitic immunity, and overcoming the challenge of drug resistance in parasitic diseases