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By activating additional receptors, dual and triple agonists can tap into a broader set of levers at once, offering the chance for greater weight reduction, improved glycemic control, and (possibly) fewer side effects compared to GLP-1 monotherapy

Thus, based on the clear and direct role of Y1-R in promoting glucose uptake in muscle, the lack of any response to GLP-1R agonism, and the glucose-reducing effects of GEP44 observed in our previous studies 16 , we predicted that GEP44 would also promote glucose uptake via interactions with the Y1-R

Three Mechanisms That Matter for Weight Loss Gastric emptying delay

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