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These compounds were found at markedly higher levels in patients with severe asthma and were shown to activate inflammatory signaling pathways long associated with asthma pathology
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2007 Jul;157(1):19-27
For instance, the PI3K/AKT signaling pathway controls inflammation by upregulating the expression of IL-10-induced genes, thus antagonizing the cytotoxic effects of pro-inflammatory factors TNF-, IL-1, IL-6, and IL-8
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