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The peptide stimulates production of VEGF (vascular endothelial growth factor) and HGF (hepatocyte growth factor), both critical for building new capillary networks
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Due to the distinct position of the conjugated N-terminal lipid between Cagri-CTR and Cagri-AMY 1 R, we also determined a structure of CTR-Gs in complex with an analogue of Cagri that lacked the lipid modification (CagriBB) to interrogate the contribution of the acylation to the conformation of Cagri-CTR complex
This is also referred to as Cobalamin