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Bariatric surgery consultation should be considered for patients with BMI 35 kg/m with obesity-related complications or 40 kg/m without complications (per ASMBS/IFSO 2022 guidelines), though insurance coverage in the US often requires BMI 35 kg/m with comorbidities or 40 kg/m without

For example, semaglutide and empagliflozin showed no significant difference in 3-point MACE (HR 1.05

GH production then stimulates the liver to secrete a powerful peptide called Insulin-like Growth Factor 1 (IGF-1)

This dual action on both glucose metabolism and appetite has made GLP-1 a therapeutic target for type 2 diabetes and obesity management