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Figure 6: Changes in sensory function grade in experimental groups 1-10 over the course of a 16 week time period following sciatic nerve repair surgery

135 Further, PRAS40 and mTOR also exerts negative feedbacks on proximal insulin signaling, PRAS40 knockdown significantly decreases Akt phosphorylation, mTORC1 binds and inhibits INSR by inducing destabilization of IRS1

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