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It is worth noting that a trial of the anti-diabetic agent pioglitazone (PPAR agonist) in ALS with the rationale of attenuating inflammation, failed to show any benefit 9

Interestingly, L585 could only be replaced with an amino acid having similar physiochemical properties, including isoleucine, methionine, and valine, without negatively affecting FcRn binding 64

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Novel AOMs, largely based around incretin therapy, may exceed weight loss of 20% [10, 75], however, most trials evaluating their efficacy and safety were performed with younger adults, and those that include older adults often poorly define the number of participants in each age group