Sherly Soleiman, MD, Founder and Medical Director of Cosmetic Injectables Center Medspa, who brings over 25 years of clinical experience to medication selection, titration, monitoring, and follow-up
While the weight-loss effect of GLP-1 analogs is largely attributed to potent suppression of food intake, this reduction in food intake affects not only fat mass but also muscle mass [39]
Researchers studying receptor cross-talk, heterodimerisation, and intracellular trafficking use retatrutide alongside selective single-receptor agonists (semaglutide for GLP-1R, native GIP analogs for GIPR, selective glucagon analogs for GCGR) to dissect the individual contributions of each pathway to downstream cellular outcomes
PMID: 30915550 | doi:10.1007/s00441-019-03016-8 Seiwerth S et al
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