6), indicating no statistically meaningful difference from the endogenous ligands within the expected systemic uncertainty of MM/PBSA (approximately 510 kcal/mol) for relative end-state comparisons (see Supplementary Note S2) [48, 49]
As discussed above, elevated circulating TMAO levels correlate with a higher risk of adverse cardiovascular events
These essential vitamins support nerve health, muscle function, hydration, and energy production
A smaller proportion is oxidised by phase I reactions catalysed by mixed function oxidases (cytochrome P450, CYP450), nicotinamide adenine dinucleotide phosphate oxidase and oxygen [13, 17]
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