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That is worth saying plainly, because the same review this page cites (Urbina 2026) found thiamine and cobalamin deficits increase over time on GLP-1 therapy, and that in patients with rapid weight loss, persistent vomiting, or very poor oral intake, suspected thiamine deficiency is a medical urgency
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With retatrutide, early trials show appetite suppression, insulin sensitivity, and blood sugar management of a GLP-1 and GIP, plus glucagon to increase calorie burn and fat oxidation
A novel case report: acute manic psychotic episode after treatment with niacin
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