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Causes of Insomnia There are many potential causes of insomnia, including: Stress related to significant life events, such as job loss, divorce, or the death of a loved one Environmental factors, such as noise, light, or temperature Changes to your sleep schedule, such as jet lag or a new work shift Genetic predisposition to insomnia Mental health issues, such as depression and anxiety Medications for colds, allergies, depression, high blood pressure, and asthma Pain or discomfort at night Caffeine, tobacco, or alcohol use, as well as the use of illicit drugs Other health conditions, such as hyperthyroidism, sleep apnea, restless legs syndrome, pregnancy, Alzheimer's disease, ADHD, PMS, and menopause Symptoms of Insomnia The primary symptoms of insomnia include: Difficulty falling asleep at night Waking up frequently during the night Waking up too early in the morning Feeling unrefreshed or tired upon waking Daytime fatigue and sleepiness Irritability and mood disturbances Difficulty concentrating or remembering things Diagnosing Insomnia To diagnose insomnia, your doctor will perform a physical exam and ask about your medical and sleep history

10.1016/j.ijbiomac.2023.124243 65 SantiniA.RonchiD.GarbelliniM.PigaD.ProttiA

In healthy tissue responding to injury, FAK-paxillin activation coordinates orderly repair

Among them, the Ser-65 residue was generally conserved across all GST classes