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Baseline liver enzyme assessment is reasonable for patients with: Pre-existing liver disease or elevated baseline transaminases Metabolic syndrome or clinical features suggesting MASLD Concurrent use of other potentially hepatotoxic medications Obesity (BMI 30 kg/m) with additional metabolic risk factors History of excessive alcohol consumption For patients with abnormal baseline liver enzymes, periodic monitoring every 3-6 months during the first year of therapy allows clinicians to assess treatment response and detect any unexpected changes
Carrying excess weight can make it hard to do activities that are important to you, like having sex with your partner, playing with your kids, driving, or exercising like you want to
Many people notice fatigue most in the first few weeks or around dose increases, then it eases as routines stabilise
Baxter SM, et al
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