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REM stays intact, no GABA-A clamp, no dependence documented in human trials
Patients typically begin at the lower dose and ramp up to the highest dose over roughly a month
doi: 10.1002/2327-6924.12247
Increased mitotic index possible
Health status considerations: Generally healthy adults with physician clearance, individuals without contraindications (pregnancy, active malignancy, severe organ disease), those willing to commit to proper administration protocols and monitoring, and patients who understand the research-purposes-only status and informed consent requirements
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