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Amide bond Ester bond is relatively weaker than amide bond, it will be rapidly hydrolyzed by esterase enzyme Example Procaine Short acting local anesthetic Procainamide Long acting antiarrhythmic T1/2 = 40-84 second T1/2 = 2.5-4.5 hr Hydrolytic phase-I metabolism Examples of prodrugs activated by hydrolytic enzymes: Dipivefrine: is a di-tertbutylcarboxy ester of adrenaline
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Ginsenoside rg1 regulates liver lipid factor metabolism in nafld model rats
In Wistar rats, shifts in light exposure altered peripheral clock gene expression and increased inflammatory markers and estrogen receptor expression in white adipose tissue, suggesting that circadian disruption may enhance estrogen-mediated pathways, which are known to be involved in breast carcinogenesis 201
R.AkhondzadehS
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