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The Short Answer Tirzepatide (Mounjaro/Zepbound) drives more weight loss than semaglutide (Ozempic/Wegovy) about 6.5 percentage points more in a head-to-head trial (-20.2% vs -13.7% over 72 weeks in adults with obesity without diabetes)

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Continued approval for this indication is dependent on confirmation of clinical benefit in a clinical trial