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While the effect is sustained as long as you continue taking GLP-1, it does not continue to increase over time

One week you're down half a pound, the next you're down three

2 Storage vs Utilization Metabolic state determines lipid fate: Fed state (Insulin dominant): Lipoprotein lipase activity Triglyceride storage in adipose tissue Fasting state (Glucagon/Epinephrine dominant): Activation of hormone-sensitive lipase Lipolysis Free fatty acids -oxidation Hepatic ketogenesis when glucose is limited Lipids are not inherently pathological

Ozempic and Wegovy Pricing Without Insurance Ozempic starts at around $1,000 a month Wegovy costs roughly $1,300 a month Notably, the manufacturer, Novo Nordisk, does provide a $499-per-month cash program through their internal pharmacy, NovoCare, for certain dosing regimens

Amasene et al., 2019