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What a useful human trial would need to measure Safety and side effects Blood levels and oral bioavailability How long the compound remains in the body Direct proof that NNMT is being inhibited Body weight, fat mass, and lean mass Glucose, insulin, liver, and lipid markers Changes after treatment stops Results compared with a placebo group Why human-equivalent dose math does not predict results Body-surface-area math can help researchers choose a starting range for future safety work
The clinical need must be considered in addition to any potential adverse outcomes for the infant
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(October 2017)
The people who are at the highest risk of B12 insufficiency or deficiency are older adults, those with atrophic gastritis, gastrointestinal disorders, pernicious anemia, those who have had gastrointestinal surgery, vegans, and vegetarians
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