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After reviewing the data I laid out in the sections above, here is how I think about the decision
label now also includes an R2 formulation with a different titration schedule Golden rule: Start low, go slow to avoid GI intolerance
While they might not be the first area you think of for body sculpting, well-defined calves contribute significantly to your overall leg aesthetics
Potential for sustained release, leading to more stable blood concentrations
This is a side effect to monitor as more Phase 3 data becomes available, though it does not appear to be a major tolerability concern based on the initial data
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