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This pigmentation effect: Can confound behavioral assays that rely on visual observation of coat color (e.g., agouti gene expression studies) Serves as a visual pharmacodynamic marker confirming MC1R engagement and compound activity Is relevant to research on melanoma biology, melanocyte function, and photoprotection May complicate blinding in non-pharmacological behavioral studies PT-141's minimal MC1R activity eliminates this pigmentation confound, making it the preferred compound for CNS-focused research where skin color changes would be undesirable

Monitoring during use can help ensure comfort and safety

These plateaus are normal parts of the process as your body adjusts to its new weight and metabolic state

10.1023/A:1005390105171

2006;291(3):R491-511