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GHK-Cu occurs naturally in human plasma at approximately 200 ng/mL at age 20, declining to about 80 ng/mL by age 60

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2007 Focused Update of the ACC/AHA/SCAI 2005 Guideline Update for Percutaneous Coronary InterventionKing SB, Smith SC, Hirshfeld JW, Jacobs AK, Morrison DA, Williams DO, Feldman TE, Kern MJ, O'Neill WW, Schaff HV, Whitlow PL, Adams C, Anderson J, Buller C, Creager M, Ettinger S, Halperin J, Hunt S, Krumholz H , Kushner F, Lytle B, Nishimura R, Page R, Riegel B, Tarkington L, Yancy C

There are plenty of relevant studies on linkage between MTHFR and human diseases including cardiovascular diseases, tumors, neurologic diseases, and psychiatric disorders 2,3,4,5

Clinical trials have established that it is generally safe to take metformin and Ozempic together