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The objective of the study is to demonstrate superiority to placebo in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain subscale score reduction and in body weight reduction from baseline to week 68 in people with a BMI 27.0 kg/m and who met clinical and radiological American College of Rheumatology Criteria for knee osteoarthritis
Interactions Blood carnitine concentrations may be decreased in children who are concomitantly taking the anticonvulsants carbamazepine, phenobarbital, phenytoin, or valproic acid
They are most intense during the first few weeks at each dose level and typically improve as the body adapts
11 with steatohepatitis (MASH), 10 with steatosis (MAS), and seven subjects (CON) without steatosis
Eur J Clin Pharmacol 2015;71:1075-82
