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Medical organizations such as the Cleveland Clinic explain that GLP-1 medications like semaglutide and tirzepatide were originally developed to treat type 2 diabetes before their powerful weight-loss effects were widely recognized

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FDA.gov / Federal Register (2024) 11

For example, most genome-wide surveys using Circle-seq/mobilome-style enrichment recover eccDNAs largely in the bp-to-low-kb range, while a smaller set of studies document rare but biologically important eccDNAs in the tens-to-hundreds of kilobases