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JCI Insight 8 (2023)

GHK-Cu (Glycyl-L-Histidyl-L-Lysine Copper) is a copper-binding tripeptide first isolated from human plasma, studied in preclinical models for its effects on gene expression, extracellular matrix remodeling, and oxidative-stress biology

Consistent with this concept, recent work has highlighted ProHyp as a bioactive collagen-derived dipeptide that may modulate fibroblast responses in tissue repair contexts [47]

BPC-157's gastric origin gives it particular relevance to gut research, and combination protocols with TB-500 explore whether the actin-sequestering activity contributes additional benefit beyond BPC-157's well-documented gastrointestinal protective effects